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MGP003196

Record overview

MGPD IDMGP003196
Gene ID7200
SpeciesHomo sapiens (Human)
Gene Namethyrotropin-releasing hormone
Gene Symbol TRH
SynonymsTRF; Pro-TRH;
Alternate namesthyrotropin releasing hormone; TSH-releasing factor; pro-thyrotropin-releasing hormone; prothyroliberin; protirelin; thyrotropin-releasing factor;
Chromosome3
Map Location3q13.3-q21
SummaryThis gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]
OrthologsView orthologs and multiple alignments for TRH

Proteins

thyrotropin releasing hormone preproprotein
Refseq ID:NP_009048
Protein GI:6005920
UniProt ID:P20396
mRNA ID:NM_007117
Length:242
RefSeq Status:
MPGPWLLLALALTLNLTGVPGGRAQPEAAQQEAVTAAEHPGLDDFLRQVERLLFLRENIQRLQGDQGEHSASQIFQSDWLSKRQHPGKREEEEEEGVEEE
EEEEGGAVGPHKRQHPGRREDEASWSVDVTQHKRQHPGRRSPWLAYAVPKRQHPGRRLADPKAQRSWEEEEEEEEREEDLMPEKRQHPGKRALGGPCGPQ
GAYGQAGLLLGLLDDLSRSQGAEEKRQHPGRRAAWVREPLEE
 
sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2432
peptide sequence: 
MPGPWLLLALALTLNLTGVPGGRA

mat_peptide: 84..86
product: thyrotropin releasing hormone
calculated_mol_wt: 380
peptide sequence: 
QHP

mat_peptide: 114..116
product: thyrotropin releasing hormone
calculated_mol_wt: 380
peptide sequence: 
QHP

mat_peptide: 135..137
product: thyrotropin releasing hormone
calculated_mol_wt: 380
peptide sequence: 
QHP

mat_peptide: 152..154
product: thyrotropin releasing hormone
calculated_mol_wt: 380
peptide sequence: 
QHP

mat_peptide: 186..188
product: thyrotropin releasing hormone
calculated_mol_wt: 380
peptide sequence: 
QHP

mat_peptide: 227..229
product: thyrotropin releasing hormone
calculated_mol_wt: 380
peptide sequence: 
QHP
 
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