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MGP003196

UniProt Annotations

Entry Information
Gene Namethyrotropin-releasing hormone
Protein EntryTRH_HUMAN
UniProt IDP20396
SpeciesHuman
Comments
Comment typeDescription
FunctionFunctions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes. {ECO:0000269|PubMed:19825978}.
SimilarityBelongs to the TRH family. {ECO:0000305}.
Subcellular LocationSecreted.
Tissue SpecificityHypothalamus. Expressed in the hair follicle epithelium (at protein level). {ECO:0000269|PubMed:19825978}.
Web ResourceName=Wikipedia; Note=Thyrotropin-releasing hormone entry; URL="http://en.wikipedia.org/wiki/Thyrotropin-releasing_hormone";
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