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MGP003337

UniProt Annotations

Entry Information
Gene Nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
Protein Entry1433B_HUMAN
UniProt IDP31946
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative initiation; Named isoforms=2; Name=Long; IsoId=P31946-1; Sequence=Displayed; Name=Short; IsoId=P31946-2; Sequence=VSP_018632; Note=Contains a N-acetylmethionine at position 1. {ECO:0000250};
FunctionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491}.
InteractionQ76353:- (xeno); NbExp=3; IntAct=EBI-359815, EBI-6248077; Q9P0K1-3:ADAM22; NbExp=2; IntAct=EBI-359815, EBI-1567267; P15056:BRAF; NbExp=3; IntAct=EBI-359815, EBI-365980; P22681:CBL; NbExp=3; IntAct=EBI-359815, EBI-518228; O00257:CBX4; NbExp=2; IntAct=EBI-359815, EBI-722425; P30304:CDC25A; NbExp=8; IntAct=EBI-359815, EBI-747671; P30305:CDC25B; NbExp=4; IntAct=EBI-359815, EBI-1051746; O94921:CDK14; NbExp=5; IntAct=EBI-359815, EBI-1043945; P67828:CSNK1A1 (xeno); NbExp=3; IntAct=EBI-359815, EBI-7540603; Q9NYF0:DACT1; NbExp=4; IntAct=EBI-359815, EBI-3951744; Q13627-2:DYRK1A; NbExp=3; IntAct=EBI-359815, EBI-1053621; Q9UQC2:GAB2; NbExp=4; IntAct=EBI-359815, EBI-975200; P55040:GEM; NbExp=3; IntAct=EBI-359815, EBI-744104; P55041:Gem (xeno); NbExp=3; IntAct=EBI-359815, EBI-7082069; P56524:HDAC4; NbExp=3; IntAct=EBI-359815, EBI-308629; Q11184:let-756 (xeno); NbExp=2; IntAct=EBI-359815, EBI-3843983; Q5S007:LRRK2; NbExp=5; IntAct=EBI-359815, EBI-5323863; Q99759:MAP3K3; NbExp=2; IntAct=EBI-359815, EBI-307281; Q99683:MAP3K5; NbExp=3; IntAct=EBI-359815, EBI-476263; Q7KZI7:MARK2; NbExp=3; IntAct=EBI-359815, EBI-516560; P27448:MARK3; NbExp=4; IntAct=EBI-359815, EBI-707595; P04049:RAF1; NbExp=17; IntAct=EBI-359815, EBI-365996; Q96TC7:RMDN3; NbExp=5; IntAct=EBI-359815, EBI-1056589; P61587:RND3; NbExp=2; IntAct=EBI-359815, EBI-1111534; P61588:Rnd3 (xeno); NbExp=5; IntAct=EBI-359815, EBI-6930266; P78362:SRPK2; NbExp=2; IntAct=EBI-359815, EBI-593303; Q8WYL5:SSH1; NbExp=3; IntAct=EBI-359815, EBI-1222387; Q91YE8:Synpo2 (xeno); NbExp=3; IntAct=EBI-359815, EBI-7623057; P49815:TSC2; NbExp=4; IntAct=EBI-359815, EBI-396587; P46937:YAP1; NbExp=5; IntAct=EBI-359815, EBI-1044059; P62258:YWHAE; NbExp=3; IntAct=EBI-359815, EBI-356498; P22893:Zfp36 (xeno); NbExp=5; IntAct=EBI-359815, EBI-647803;
PtmIsoform Short contains a N-acetylmethionine at position 1. {ECO:0000250}.
PtmThe alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. {ECO:0000250}.
SimilarityBelongs to the 14-3-3 family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SubunitHomodimer. Interacts with SAMSN1 and PRKCE (By similarity). Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues. Interacts with GAB2 and YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with PKA-phosphorylated AANAT. Interacts with MYO1C and SIRT2. {ECO:0000250, ECO:0000269|PubMed:11427721, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:17085597, ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18249187, ECO:0000269|PubMed:19172738, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:24636949}.
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