MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003484

UniProt Annotations

Entry Information
Gene Namecell division cycle 7
Protein EntryCDC7_HUMAN
UniProt IDO00311
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=1; Comment=A number of isoforms may be produced.; Name=1; IsoId=O00311-1; Sequence=Displayed;
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
FunctionSeems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. {ECO:0000269|PubMed:12065429}.
InteractionQ9BTE3:MCMBP; NbExp=2; IntAct=EBI-374980, EBI-749378;
SimilarityBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily. {ECO:0000255|PROSITE- ProRule:PRU00159}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Subcellular LocationNucleus.
SubunitForms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdc7/";
  logo