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MGP003553

Record overview

MGPD IDMGP003553
Gene ID8440
SpeciesHomo sapiens (Human)
Gene NameNCK adaptor protein 2
Gene Symbol NCK2
SynonymsGRB4; NCKbeta;
Alternate namescytoplasmic protein NCK2; SH2/SH3 adaptor protein NCK-beta; growth factor receptor-bound protein 4; noncatalytic region of tyrosine kinase, beta;
Chromosome2
Map Location2q12
SummaryThis gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for NCK2

Proteins

cytoplasmic protein NCK2 isoform A
Refseq ID:NP_003572
Protein GI:52630423
UniProt ID:O43639
mRNA ID:NM_003581
Length:380
RefSeq Status:
MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYP
ANGSGADRIYDLNIPAFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLSLRKGASLSNGQGSRVLHVV
QTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALN
ERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIGQRRFHTMDELVEHYKKAPIFTSEHGEKLYLVRALQ
 
cytoplasmic protein NCK2 isoform A
Refseq ID:NP_001004720
Protein GI:52630425
UniProt ID:O43639
mRNA ID:NM_001004720
Length:380
RefSeq Status:
Protein sequence is identical to GI:52630423 (mRNA isoform)
 
cytoplasmic protein NCK2 isoform B
Refseq ID:NP_001004722
Protein GI:52630427
UniProt ID:E7ERP6
mRNA ID:NM_001004722
Length:83
RefSeq Status:
MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSLVKNLKDTLAQRLLRVP
 
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