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MGP003553

UniProt Annotations

Entry Information
Gene NameNCK adaptor protein 2
Protein EntryNCK2_HUMAN
UniProt IDO43639
SpeciesHuman
Comments
Comment typeDescription
FunctionAdapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242}.
InteractionQ08345:DDR1; NbExp=3; IntAct=EBI-713635, EBI-711879; P52799:EFNB2; NbExp=7; IntAct=EBI-713635, EBI-7532268; P04626:ERBB2; NbExp=2; IntAct=EBI-713635, EBI-641062; P21860:ERBB3; NbExp=2; IntAct=EBI-713635, EBI-720706; Q13480:GAB1; NbExp=5; IntAct=EBI-713635, EBI-517684; P10721:KIT; NbExp=2; IntAct=EBI-713635, EBI-1379503; P48059:LIMS1; NbExp=2; IntAct=EBI-713635, EBI-306928; P08581:MET; NbExp=2; IntAct=EBI-713635, EBI-1039152; Q7L0Q8:RHOU; NbExp=6; IntAct=EBI-713635, EBI-1638043; Q96L33:RHOV; NbExp=4; IntAct=EBI-713635, EBI-8538631; Q9NQC3:RTN4; NbExp=2; IntAct=EBI-713635, EBI-715945; P0CG48:UBC; NbExp=2; IntAct=EBI-713635, EBI-3390054;
PtmPhosphorylated. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:18088087, ECO:0000269|PubMed:19690332}.
SimilarityContains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
SimilarityContains 3 SH3 domains. {ECO:0000255|PROSITE- ProRule:PRU00192}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:16835242}. Endoplasmic reticulum {ECO:0000269|PubMed:16835242}.
SubunitInteracts with DOCK1, LIMS1 and TGFB1I1. Part of a complex containing PPP1R15B, PP1 and NCK2. Interacts with FASLG (By similarity). Interacts with AXL. Interacts with PAK1, PKN2 and SOS1. Interacts (via SH2 domain) with EGFR. Interacts (via SH2 domain) with DDR1. {ECO:0000250, ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:10330411, ECO:0000269|PubMed:11240126, ECO:0000269|PubMed:12470648, ECO:0000269|PubMed:16337946, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:19807924, ECO:0000269|PubMed:9843575}.
Tissue SpecificityUbiquitous.
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