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MGP003715

Record overview

MGPD IDMGP003715
Gene ID8841
SpeciesHomo sapiens (Human)
Gene Namehistone deacetylase 3
Gene Symbol HDAC3
SynonymsHD3; RPD3; RPD3-2;
Alternate nameshistone deacetylase 3; SMAP45;
Chromosome5
Map Location5q31
EC Number3.5.1.98
SummaryHistones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HDAC3

Proteins

histone deacetylase 3
Refseq ID:NP_003874
Protein GI:13128862
UniProt ID:O15379
mRNA ID:NM_003883
Length:428
RefSeq Status:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGL
FEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFF
PGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGP
EENYSRPEAPNEFYDGDHDNDKESDVEI
 
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