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MGP003715

UniProt Annotations

Entry Information
Gene Namehistone deacetylase 3
Protein EntryHDAC3_HUMAN
UniProt IDO15379
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=RPD3-2B; IsoId=O15379-1; Sequence=Displayed; Name=2; Synonyms=RPD3-2A; IsoId=O15379-2; Sequence=VSP_002079;
Catalytic ActivityHydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
FunctionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys- 27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803). {ECO:0000269|PubMed:21444723, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:25190803}.
InductionUp-regulated by disturbed flow in umbilical vein endothelial cells in vitro (PubMed:25190803).
InteractionQ9UKG1:APPL1; NbExp=2; IntAct=EBI-607682, EBI-741243; Q7L2E3:DHX30; NbExp=3; IntAct=EBI-607682, EBI-1211456; P08393:ICP0 (xeno); NbExp=3; IntAct=EBI-607682, EBI-6148881; O60341:KDM1A; NbExp=4; IntAct=EBI-607682, EBI-710124; Q969R5:L3MBTL2; NbExp=6; IntAct=EBI-607682, EBI-739909; P43356:MAGEA2B; NbExp=4; IntAct=EBI-607682, EBI-5650739; Q9UIS9:MBD1; NbExp=3; IntAct=EBI-607682, EBI-867196; P01106:MYC; NbExp=6; IntAct=EBI-607682, EBI-447544; O75376:NCOR1; NbExp=3; IntAct=EBI-607682, EBI-347233; Q9Y5X4:NR2E3; NbExp=2; IntAct=EBI-607682, EBI-7216962; P48552:NRIP1; NbExp=2; IntAct=EBI-607682, EBI-746484; Q8CBD1:Nrip1 (xeno); NbExp=2; IntAct=EBI-607682, EBI-1771626; P60510:PPP4C; NbExp=4; IntAct=EBI-607682, EBI-1046072; Q15022:SUZ12; NbExp=7; IntAct=EBI-607682, EBI-1264675; P12504:vif (xeno); NbExp=2; IntAct=EBI-607682, EBI-779991;
PtmSumoylated in vitro. {ECO:0000269|PubMed:12032081}.
SimilarityBelongs to the histone deacetylase family. HD type 1 subfamily. {ECO:0000305}.
Subcellular LocationNucleus. Cytoplasm {ECO:0000269|PubMed:25190803}. Note=Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). {ECO:0000269|PubMed:25190803}.
SubunitInteracts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with DAXX, HDAC10 and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY. Interacts with BTBD14B. Interacts with GLIS2. Interacts (via the DNA-binding domain) with NR2C1; the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation. Component of the Notch corepressor complex. Interacts with CBFA2T3 and NKAP. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with and deacetylates MAPK14. Interacts with ZMYND15. Interact with SMRT/NCOR2 and BCL6 on DNA enhancer elements. Interacts with INSM1 (PubMed:10655483, PubMed:10669754, PubMed:10860984, PubMed:10898795, PubMed:11006275, PubMed:11466315, PubMed:11533236, PubMed:11861901, PubMed:14525983, PubMed:14633989, PubMed:15297880, PubMed:15927959, PubMed:16569215, PubMed:18417529, PubMed:19409814, PubMed:23911289). Interacts with XBP1 isoform 1; the interaction occurs in endothelial cell (EC) under disturbed flow (PubMed:25190803). {ECO:0000269|PubMed:10655483, ECO:0000269|PubMed:10669754, ECO:0000269|PubMed:10860984, ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:11006275, ECO:0000269|PubMed:11466315, ECO:0000269|PubMed:11533236, ECO:0000269|PubMed:11861901, ECO:0000269|PubMed:14525983, ECO:0000269|PubMed:14633989, ECO:0000269|PubMed:15297880, ECO:0000269|PubMed:15927959, ECO:0000269|PubMed:16569215, ECO:0000269|PubMed:18417529, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:25190803}.
Tissue SpecificityWidely expressed.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/HDAC3ID40804ch5q31.html";
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