MGP Database

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MGP003715

Ontology/Pathway Information

Entrez Gene ID8841
Gene Namehistone deacetylase 3
Gene Symbol HDAC3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005794 IDA:HPACGolgi apparatus
GO:0000118 TAS:UniProtKBChistone deacetylase complex
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 IDA:HPACplasma membrane
GO:0005876 IDA:UniProtKBCspindle microtubule
GO:0017053 IDA:UniProtKBCtranscriptional repressor complex
GO:0003682 IDA:UniProtKBFchromatin binding
GO:0031490 IEA:EnsemblFchromatin DNA binding
GO:0030332 IPI:UniProtKBFcyclin binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0004407 IMP:UniProtKBFhistone deacetylase activity
GO:0042826 IPI:BHF-UCLFhistone deacetylase binding
GO:0032041 IEA:UniProtKB-ECFNAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0097372 IEA:UniProtKB-ECFNAD-dependent histone deacetylase activity (H3-K18 specific)
GO:0046969 IEA:UniProtKB-ECFNAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 IEA:UniProtKB-ECFNAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0033558 IDA:UniProtKBFprotein deacetylase activity
GO:0003714 IDA:UniProtKBFtranscription corepressor activity
GO:0008134 IPI:UniProtKBFtranscription factor binding
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0071498 IDA:UniProtKBPcellular response to fluid shear stress
GO:0016568 TAS:UniProtKBPchromatin modification
GO:0032922 IEA:EnsemblPcircadian regulation of gene expression
GO:0043066 TAS:ProtIncPnegative regulation of apoptotic process
GO:0045786 TAS:ReactomePnegative regulation of cell cycle
GO:0046329 IMP:UniProtKBPnegative regulation of JNK cascade
GO:0045892 IMP:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0000122 IDA:UniProtKBPnegative regulation of transcription from RNA polymerase II promoter
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0007219 TAS:ReactomePNotch signaling pathway
GO:0001934 IDA:UniProtKBPpositive regulation of protein phosphorylation
GO:0032008 IMP:UniProtKBPpositive regulation of TOR signaling
GO:0042993 IDA:UniProtKBPpositive regulation of transcription factor import into nucleus
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0006476 IDA:UniProtKBPprotein deacetylation
GO:0007346 IEA:EnsemblPregulation of mitotic cell cycle
GO:0040014 IEA:EnsemblPregulation of multicellular organism growth
GO:0031647 IDA:UniProtKBPregulation of protein stability
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0051225 IMP:UniProtKBPspindle assembly
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111118BMAL1:CLOCK,NPAS2 activates circadian gene expression
REACT_264165Chromatin modifying enzymes
REACT_264155Chromatin organization
REACT_24941Circadian Clock
REACT_160254Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160243Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_111045Developmental Biology
REACT_116125Disease
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_263923HDACs deacetylate histones
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_264351Mitochondrial biogenesis
REACT_118780NOTCH1 Intracellular Domain Regulates Transcription
REACT_264135Organelle biogenesis and maintenance
REACT_13695p75NTR negatively regulates cell cycle via SC1
REACT_13776p75 NTR receptor-mediated signalling
REACT_116145PPARA activates gene expression
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_118789REV-ERBA represses gene expression
REACT_118659RORA activates circadian gene expression
REACT_299Signaling by NOTCH
REACT_118859Signaling by NOTCH1
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_264212Transcriptional activation of mitochondrial biogenesis
REACT_27161Transcriptional regulation of white adipocyte differentiation
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