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MGP004317

Record overview

MGPD IDMGP004317
Gene ID10637
SpeciesHomo sapiens (Human)
Gene Nameleft-right determination factor 1
Gene Symbol LEFTY1
SynonymsLEFTB; LEFTYB;
Alternate namesleft-right determination factor 1; left-right determination factor B; left-right determination, factor B; protein lefty-1; protein lefty-B;
Chromosome1
Map Location1q42.1
SummaryThis gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for LEFTY1

Proteins

left-right determination factor 1 preproprotein
Refseq ID:NP_066277
Protein GI:10337603
UniProt ID:O75610
mRNA ID:NM_020997
Length:366
RefSeq Status:
MQPLWLCWALWVLPLASPGAALTGEQLLGSLLRQLQLKEVPTLDRADMEELVIPTHVRAQYVALLQRSHGDRSRGKRFSQSFREVAGRFLALEASTHLLV
FGMEQRLPPNSELVQAVLRLFQEPVPKAALHRHGRLSPRSARARVTVEWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQ
VSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLGDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMKWAENWVLEPPGFLAYECVGTCRQP
PEALAFKWPFLGPRQCIASETDSLPMIVSIKEGGRTRPQVVSLPNMRVQKCSCASDGALVPRRLQP
 
sig_peptide: 1..21
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2324
peptide sequence: 
MQPLWLCWALWVLPLASPGAA

mat_peptide: 77..366
product: left-right determination factor 1
calculated_mol_wt: 32355
peptide sequence: 
RFSQSFREVAGRFLALEASTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPKAALHRHGRLSPRSARARVTVEWLRVRDDGSNRTSLIDSRLVSVHESGWK
AFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLGDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMK
WAENWVLEPPGFLAYECVGTCRQPPEALAFKWPFLGPRQCIASETDSLPMIVSIKEGGRTRPQVVSLPNMRVQKCSCASDGALVPRRLQP
 
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