MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP006046

UniProt Annotations

Entry Information
Gene Nametripartite motif containing 8
Protein EntryTRIM8_HUMAN
UniProt IDQ9BZR9
SpeciesHuman
Comments
Comment typeDescription
DomainThe coiled coil domain is required for homodimerization.
DomainThe region immediately C-terminal to the RING motif is sufficient to mediate the interaction with SOCS1. {ECO:0000250}.
FunctionProbable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1. {ECO:0000250}.
InteractionSelf; NbExp=3; IntAct=EBI-2340370, EBI-2340370;
PathwayProtein modification; protein ubiquitination.
SimilarityBelongs to the TRIM/RBCC family. {ECO:0000305}.
SimilarityContains 1 RING-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00175}.
SimilarityContains 2 B box-type zinc fingers. {ECO:0000305}.
SubunitHomodimer. Interacts with SOCS1 (via) SH2 domain and SOCS box (By similarity). {ECO:0000250}.
Tissue SpecificityWidely expressed.
  logo