Summary of Study ST000260
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000211. The data can be accessed directly via it's Project DOI: 10.21228/M84598 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000260 |
| Study Title | Analysis of DJ-1 Knockout Mouse Brains |
| Study Type | Mouse genotype comparison |
| Study Summary | We analyzed metabolites in the brains of wild type mice and DJ-1 knockout mice. The DJ-1 knockout mouse is a model of an inherited form of Parkinson's disease. |
| Institute | National Institute on Aging |
| Department | Laboratory of Neurogenetics |
| Laboratory | Cell Biology and Gene Expression Section |
| Last Name | Hauser |
| First Name | David |
| Address | 35 Lincoln Drive, BLDG 35, Room 1A-1012, Bethesda, MD 20892 |
| hauserd@mail.nih.gov | |
| Phone | 301-435-8995 |
| Submit Date | 2015-09-17 |
| Num Groups | 2 |
| Total Subjects | 25 |
| Raw Data Available | No |
| Analysis Type Detail | GC-MS/LC-MS |
| Release Date | 2017-10-03 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Project:
| Project ID: | PR000211 |
| Project DOI: | doi: 10.21228/M84598 |
| Project Title: | Metabolic Response to the Loss of DJ-1 |
| Project Type: | Comparison of the metabolic responses to the loss of DJ-1 in model organisms |
| Project Summary: | Mutations in the DJ-1 gene cause rare forms of autosomal recessive Parkinson's disease in humans, and increased levels of DJ-1 protein are often found in cancers. Thus, understanding the precise function of DJ-1 is of broad interest. We hypothesized that analyzing differences in metabolites between organisms with and without DJ-1 may lead to clues about the protein's function. Here, we present the results of our ongoing studies using multiple different model organisms. |
| Institute: | National Institute on Aging |
| Department: | Laboratory of Neurogenetics |
| Laboratory: | Cell Biology and Gene Expression Section |
| Last Name: | Cookson |
| First Name: | Mark |
| Address: | 35 Lincoln Drive, BLDG 35, Room 1A116, Bethesda, MD, 20892 |
| Email: | cookson@mail.nih.gov |
| Phone: | -- |
| Funding Source: | The NIH Intramural Program, National Institute on Aging |
