Summary of Study ST003046

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001896. The data can be accessed directly via it's Project DOI: 10.21228/M8N72Z This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST003046
Study Title	Multi-Omics Plasma Signatures of Severe Injury with Influence of REBOA Intervention in a Swine Model.
Study Type	Original Research
Study Summary	Swine experienced controlled severe injury involving combinations of trauma, hemorrhagic shock, and disseminated complex blast injury (DCBI). After a period of hemorrhagic shock, resuscitation was performed using Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) and shed blood transfusion. Blood samples were collected from sham and experiment swine. Blood samples for experiment swine were collected at baseline and periodically through the monitored time course. The plasma fraction were then subjected to mass spectrometry based metabolomics. Results indicated intervention using REBOA following polytrauma in our swine model induced distinct multi-omics alterations as a function of placement location. Namely, aortic balloon placement in Zone-1 worsened ischemic damage and mitochondrial dysfunction, patterns that continued through the monitored time course.
Institute	University of Colorado Anschutz Medical Campus
Laboratory	The D'Alessandro Lab
Last Name	LaCroix
First Name	Ian
Address	RC1-S L18-9403G E 17th Ave. Aurora, CO 80045
Email	ian.lacroix@cuanschutz.edu
Phone	(303) 724-0096
Submit Date	2024-01-17
Raw Data Available	Yes
Raw Data File Type(s)	mzXML, raw(Thermo)
Analysis Type Detail	LC-MS
Release Date	2024-02-08
Release Version	1

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Treatment:

Treatment ID:	TR003170
Treatment Summary:	the DCBI model included blast traumatic brain injury (bTBI), tissue injury through bilateral open femur fractures, followed by severe fixed pressure targeted hemorrhagic shock (HS). Zone-I aortic occlusion (AO) was performed using the ER-REBOA Catheter (Prytime Medical Devices, Inc., Boerne, TX). The catheter was inserted through a 7 Fr sheath placed in the common femoral artery, was advanced to 50 cm, and inflated using 6 mL of normal saline for Zone-I AO and placed at 26 cm with 5 ml of saline for Zone-III, and both were maintained for the final 30 minutes of the HS phase.

Treatment ID:

TR003170

Treatment Summary:

the DCBI model included blast traumatic brain injury (bTBI), tissue injury through bilateral open femur fractures, followed by severe fixed pressure targeted hemorrhagic shock (HS). Zone-I aortic occlusion (AO) was performed using the ER-REBOA Catheter (Prytime Medical Devices, Inc., Boerne, TX). The catheter was inserted through a 7 Fr sheath placed in the common femoral artery, was advanced to 50 cm, and inflated using 6 mL of normal saline for Zone-I AO and placed at 26 cm with 5 ml of saline for Zone-III, and both were maintained for the final 30 minutes of the HS phase.