Summary of Study ST001948

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001235. The data can be accessed directly via it's Project DOI: 10.21228/M82T49 This work is supported by NIH grant, U2C- DK119886.

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Study IDST001948
Study TitleMetabolites Associated with Gestational Diabetes in Plasma
Study TypeCase:Control ancillary analysis of RCT
Study SummaryGestational diabetes mellitus (GDM) significantly increases maternal and fetal health risks, but factors predictive of GDM are poorly understood. Plasma metabolomics analyses were conducted in early pregnancy to identify potential biomarkers for early prediction of Gestational Diabetes Mellitus (GDM). Sixty-eight pregnant women with overweight/obesity from a clinical trial of a lifestyle intervention were included. Participants who developed GDM (n=34; GDM group) were matched on treatment group, age, body mass index, and ethnicity with those who did not develop GDM (n=34; Non-GDM group). Blood draws were completed early in pregnancy (10-16 weeks). Plasma samples were analyzed by UPLC-MS using three metabolomics assays.
Institute
California Polytechnic State University
DepartmentFood Science and Nutrition
LaboratoryCal Poly Metabolomics Service Center
Last NameLa Frano
First NameMichael
AddressCALIFORNIA POLYTECHNIC STATE UNIVERSITY, 1 GRAND AVE
Emailmlafrano@calpoly.edu
Phone18057566233
Submit Date2021-10-13
Num Groups2
Total Subjects68
Num Females68
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2021-11-04
Release Version1
Michael La Frano Michael La Frano
https://dx.doi.org/10.21228/M82T49
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN003170 AN003171 AN003172
Analysis type MS MS MS
Chromatography type HILIC HILIC Reversed phase
Chromatography system Waters Acquity I-Class Waters Acquity I-Class Waters Acquity I-Class
Column Phenomenex Luna NH2 (150 x 2.1mm,3um) Waters Atlantis HILIC (150 x 2.1mm,3um) Grace Prosphere HP C4 (150 x 3mm,3um)
MS Type ESI ESI ESI
MS instrument type QTRAP QTRAP QTRAP
MS instrument name ABI Sciex 4000 QTrap ABI Sciex 4000 QTrap ABI Sciex 4000 QTrap
Ion Mode NEGATIVE POSITIVE POSITIVE
Units Peak Area Peak Area Peak Area

Chromatography:

Chromatography ID:CH002343
Methods Filename:La_Frano_Lab_Methods_Doc_v8.pdf
Instrument Name:Waters Acquity I-Class
Column Name:Phenomenex Luna NH2 (150 x 2.1mm,3um)
Chromatography Type:HILIC
  
Chromatography ID:CH002344
Methods Filename:La_Frano_Lab_Methods_Doc_v8.pdf
Instrument Name:Waters Acquity I-Class
Column Name:Waters Atlantis HILIC (150 x 2.1mm,3um)
Chromatography Type:HILIC
  
Chromatography ID:CH002345
Methods Filename:La_Frano_Lab_Methods_Doc_v8.pdf
Instrument Name:Waters Acquity I-Class
Column Name:Grace Prosphere HP C4 (150 x 3mm,3um)
Chromatography Type:Reversed phase
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