Summary of Study ST001948

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001235. The data can be accessed directly via it's Project DOI: 10.21228/M82T49 This work is supported by NIH grant, U2C- DK119886.


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Study IDST001948
Study TitleMetabolites Associated with Gestational Diabetes in Plasma
Study TypeCase:Control ancillary analysis of RCT
Study SummaryGestational diabetes mellitus (GDM) significantly increases maternal and fetal health risks, but factors predictive of GDM are poorly understood. Plasma metabolomics analyses were conducted in early pregnancy to identify potential biomarkers for early prediction of Gestational Diabetes Mellitus (GDM). Sixty-eight pregnant women with overweight/obesity from a clinical trial of a lifestyle intervention were included. Participants who developed GDM (n=34; GDM group) were matched on treatment group, age, body mass index, and ethnicity with those who did not develop GDM (n=34; Non-GDM group). Blood draws were completed early in pregnancy (10-16 weeks). Plasma samples were analyzed by UPLC-MS using three metabolomics assays.
California Polytechnic State University
DepartmentFood Science and Nutrition
LaboratoryCal Poly Metabolomics Service Center
Last NameLa Frano
First NameMichael
Submit Date2021-10-13
Num Groups2
Total Subjects68
Num Females68
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2021-11-04
Release Version1
Michael La Frano Michael La Frano application/zip

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Collection ID:CO002019
Collection Summary:Blood samples (plasma) were collected from participants with GDM and non-GDM affected pregnancies during 10-16 weeks gestation (GDM for GDM cases and Non-GDM for control cases).
Collection Protocol Filename:La_Frano_Lab_Methods_Doc_v8.pdf
Sample Type:Blood (plasma)