Summary of Study ST002968

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001847. The data can be accessed directly via it's Project DOI: 10.21228/M8ZT64 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002968
Study TitleUntargeted metabolomic studies of the PSD95-nNOS uncoupling agent against post-stroke depression in rats
Study Typeresearch
Study SummaryTo elucidate the antidepressant mechanisms of the PSD95-nNOS decoupler ZL006 using an innovative integrated metabolomics approach.
Institute
Nanjing University of Science & Technology
DepartmentCenter of Molecular Metabolism
Last NameHu
First NameYudie
AddressNanjing University of Science and Technology
Emailhuyudie@njust.edu.cn
Phone+8618759270506
Submit Date2023-11-08
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2023-11-28
Release Version1
Yudie Hu Yudie Hu
https://dx.doi.org/10.21228/M8ZT64
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN004876 AN004877
Analysis type MS MS
Chromatography type Reversed phase Reversed phase
Chromatography system Shimadzu 20AD Shimadzu 20AD
Column Waters ACQUITY UPLC BEH C18 (100 x 2.1mm,1.7um) Waters ACQUITY UPLC BEH C18 (100 x 2.1mm,1.7um)
MS Type ESI ESI
MS instrument type Triple TOF Triple TOF
MS instrument name ABI Sciex 5600+ TripleTOF ABI Sciex 5600+ TripleTOF
Ion Mode POSITIVE NEGATIVE
Units log2(peak area) log2 (peak area)

Chromatography:

Chromatography ID:CH003679
Instrument Name:Shimadzu 20AD
Column Name:Waters ACQUITY UPLC BEH C18 (100 x 2.1mm,1.7um)
Column Temperature:40
Flow Gradient:0-3 min,75%B;3-6 min,75%B-70%B;6-7 min,70%B-65%B;7-10 min,65%B-40%B;10-10.1 min,40%B-95%B;10.1-15 min,95%B
Flow Rate:0.3 mL/min
Solvent A:100% water; 0.1% formic acid
Solvent B:100% acetonitrile
Chromatography Type:Reversed phase
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