Summary of Study ST001660

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001065. The data can be accessed directly via it's Project DOI: 10.21228/M81Q3K This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001660
Study TitlePlasmodium falciparum metabolomics as a result of treatment with putative acetyl-CoA synthetase inhibitors
Study SummaryPlasmodium falciparum cells in culture were treated with respective compounds for 2.5 hours at 10xIC50 values. Metabolites were isolated using 90% methanol, dried, reconstituted in HPLC-grade water, and analyzed by HPLC/MS. Resulting data were analyzed and compiled to generate study data.
Pennsylvania State University
LaboratoryLlinás Laboratory
Last NameLlinás
First NameManuel
AddressW126 Millennium Science Complex, University Park, PENNSYLVANIA, 16802, USA
Submit Date2021-01-22
Num Groups3
Total Subjects24
Raw Data AvailableYes
Raw Data File Type(s)mzXML
Analysis Type DetailLC-MS
Release Date2021-06-01
Release Version1
Manuel Llinás Manuel Llinás application/zip

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Collection ID:CO001730
Collection Summary:Plasmodium falciparum 3D7 parasites were cultured in RPMI 1640 medium and magnetically enriched to increase the infected to uninfected RBC ratio. Following hemocytometer counts, 1x10^8 parasites were measured per condition into 5 mL of total media for 2.5 hours in the presence of drug. Medium was aspirated until 1 mL remained on each sample, the sample was transferred to a micro-centrifuge tube, spun, and the medium was aspirated.
Collection Protocol Filename:Metabolite_Extraction_for_LCMS_2017.pdf
Sample Type:Cultured cells
Collection Location:Millenium Science Complex, University Park, Pennsylvania
Storage Conditions:-80℃
Collection Vials:1.5 mL eppendorf
Storage Vials:1.5 mL eppendorf
Collection Tube Temp:On ice
Tissue Cell Quantity Taken:1x10^8 cells per sample in 1 mL total volume