Summary of Study ST001660

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001065. The data can be accessed directly via it's Project DOI: 10.21228/M81Q3K This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001660
Study TitlePlasmodium falciparum metabolomics as a result of treatment with putative acetyl-CoA synthetase inhibitors
Study SummaryPlasmodium falciparum cells in culture were treated with respective compounds for 2.5 hours at 10xIC50 values. Metabolites were isolated using 90% methanol, dried, reconstituted in HPLC-grade water, and analyzed by HPLC/MS. Resulting data were analyzed and compiled to generate study data.
Pennsylvania State University
LaboratoryLlinás Laboratory
Last NameLlinás
First NameManuel
AddressW126 Millennium Science Complex, University Park, PENNSYLVANIA, 16802, USA
Submit Date2021-01-22
Num Groups3
Total Subjects24
Raw Data AvailableYes
Raw Data File Type(s)mzXML
Analysis Type DetailLC-MS
Release Date2021-06-01
Release Version1
Manuel Llinás Manuel Llinás application/zip

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Project ID:PR001065
Project DOI:doi: 10.21228/M81Q3K
Project Title:Plasmodium falciparum metabolomics as a result of treatment with putative acetyl-CoA synthetase inhibitors
Project Summary:Plasmodium falciparum is the most virulent species of parasites that cause malaria. Current drug efforts that are used to combat this deadly disease often employ pharmacologic strategies that inhibit critical parasite metabolic functions. Compounds used in the present study have generated resistance mutations in major acetyl-CoA producing enzymes. Hence, we set out to test the metabolic effects of these compounds on Plasmodium falciparum parasites including those on acetyl-CoA production by treating parasites for 2.5 hours under 10xIC50 of the test compounds. We used a targeted HPLC/mass spectrometry-based approach to analyze parasite metabolism. We find that multiple compounds tested in these studies have led to relative decreases in acetyl-CoA abundance compared to control parasite conditions. These studies are necessary for understanding pharmacology effects on the most virulent human malaria parasite.
Institute:Pennsylvania State University
Laboratory:Llinás Laboratory
Last Name:Llinás
First Name:Manuel
Address:W126 Millennium Science Complex, University Park, PENNSYLVANIA, 16802, USA
Funding Source:This work was supported by the Bill and Melinda Gates Foundation (OPP1054480)