Summary of Study ST002550
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001642. The data can be accessed directly via it's Project DOI: 10.21228/M8FX54 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002550 |
| Study Title | Targeted metabolomics for ARDS |
| Study Summary | Acute respiratory distress syndrome (ARDS) is a heterogeneous disease in its etiology and clinical aspects, and it has been an important interest in how to diagnose it and classify its subtypes, and apply them to treatment. Metabolomics is becoming important for identifying ARDS biology and distinguishing subtypes. The aim of this study is to identify metabolites distinguishing sepsis-induced ARDS patients from healthy controls using a targeted metabolomics approach, and to find out whether direct and indirect ARDS are metabolically distinct groups and confirm their metabolites and associated pathways. Targeted metabolomics was performed to explore metabolome changes between pARDS (pediatric ARDS) and eARDS. |
| Institute | Asan Medical Center |
| Last Name | Yoo |
| First Name | Hyun Ju |
| Address | 88, Olympic-ro 43-gil, Songpa-gu |
| yoohyunju@amc.seoul.kr | |
| Phone | 0230104029 |
| Submit Date | 2023-03-30 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2023-07-06 |
| Release Version | 1 |
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Collection:
| Collection ID: | CO002643 |
| Collection Summary: | This study was approved by the Asan Institutional Review Board (IRB No. 2019-1017). The inclusion criteria for the cohort were as follows: adult patients aged > 18 years, patients admitted to the medical intensive care unit (ICU) and clinically diagnosed as sepsis according to the Sepsis-2 definition16, and those enrolled within 48 hours of ICU admission. The patients' serum was collected at the time of sepsis cohort enrollment. The healthy control registry included healthy people who visited the Health Screening and Promotion Center at Asan Medical Center. The diagnosis of direct ARDS and indirect ARDS was made through a blind review by the two intensivists reaching the same judgment.Since the eligible ARDS patients belonged to the sepsis cohort, the direct ARDS group included pulmonary ARDS patients with pneumonia-induced sepsis, and the indirect ARDS included extrapulmonary ARDS patients with non-pneumonia induced sepsis. |
| Sample Type: | Blood (serum) |
| Storage Conditions: | -80℃ |
