Summary of Study ST002550
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001642. The data can be accessed directly via it's Project DOI: 10.21228/M8FX54 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002550 |
| Study Title | Targeted metabolomics for ARDS |
| Study Summary | Acute respiratory distress syndrome (ARDS) is a heterogeneous disease in its etiology and clinical aspects, and it has been an important interest in how to diagnose it and classify its subtypes, and apply them to treatment. Metabolomics is becoming important for identifying ARDS biology and distinguishing subtypes. The aim of this study is to identify metabolites distinguishing sepsis-induced ARDS patients from healthy controls using a targeted metabolomics approach, and to find out whether direct and indirect ARDS are metabolically distinct groups and confirm their metabolites and associated pathways. Targeted metabolomics was performed to explore metabolome changes between pARDS (pediatric ARDS) and eARDS. |
| Institute | Asan Medical Center |
| Last Name | Yoo |
| First Name | Hyun Ju |
| Address | 88, Olympic-ro 43-gil, Songpa-gu |
| yoohyunju@amc.seoul.kr | |
| Phone | 0230104029 |
| Submit Date | 2023-03-30 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2023-07-06 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
| Analysis ID | AN004198 | AN004199 |
|---|---|---|
| Analysis type | MS | MS |
| Chromatography type | Reversed phase | Reversed phase |
| Chromatography system | Agilent 1290 | Agilent 1290 |
| Column | Agilent ZORBAX Eclipse Plus C18 (50 x 2.1mm,1.8um) | Agilent Pursuit 5 C18 (150 x 2.1mm,5um) |
| MS Type | ESI | ESI |
| MS instrument type | QTRAP | QTRAP |
| MS instrument name | ABI Sciex 5500 QTrap | ABI Sciex 5500 QTrap |
| Ion Mode | POSITIVE | POSITIVE |
| Units | nM | nM |
MS:
| MS ID: | MS003945 |
| Analysis ID: | AN004198 |
| Instrument Name: | ABI Sciex 5500 QTrap |
| Instrument Type: | QTRAP |
| MS Type: | ESI |
| MS Comments: | Data analysis was performed using Analyst 1.5.2 software. Extracted ion chromatograms (EIC) corresponding to each metabolite were used for quantitation (MRM). The area under the curve of each EIC was normalized to that of the internal standard. For metabolites related to PC/PE profiling, the peak area ratio of each metabolite to that of the internal standard was used for a relative comparison. For plasmalogens, the calibration range was generally 0.1 nM to 10 μM with R2>0.99 |
| Ion Mode: | POSITIVE |
| MS ID: | MS003946 |
| Analysis ID: | AN004199 |
| Instrument Name: | ABI Sciex 5500 QTrap |
| Instrument Type: | QTRAP |
| MS Type: | ESI |
| MS Comments: | Data analysis was performed using Analyst 1.5.2 software. Extracted ion chromatograms (EIC) corresponding to each metabolite were used for quantitation (MRM). The area under the curve of each EIC was normalized to that of the internal standard. For ceramides and sphingomyelins, the calibration range was generally 0.1 nM to 10 μM with R2>0.99 |
| Ion Mode: | POSITIVE |
