Summary of Study ST002874

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001796. The data can be accessed directly via it's Project DOI: 10.21228/M8JX52 This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002874
Study TitleQuantification of metabolites in kynurenine pathway
Study SummaryUrine samples were collected from two independent cohorts. Patients with LN were classified into proliferative (class III/IV) and membranous (class V) by kidney histopathology. Quantification of metabolites in kynurenine pathway was performed using LC-MS/MS.
Institute
Mahidol University
DepartmentSiriraj Metabolomics and Phenomics Center
LaboratorySiriraj Center of Research Excellence in Metabolomics and Systems Biology
Last NameKhoomrung
First NameSakda
Address2 Wanglang Road Bangkoknoi, Bangkok 10700, Thailand
Emailsakda.kho@mahidol.edu
Phone024195511
Submit Date2023-09-25
Num Groups2
Total Subjects117
Publicationshttps://doi.org/10.1016/j.isci.2021.103355
Raw Data AvailableYes
Raw Data File Type(s)raw(Waters)
Analysis Type DetailLC-MS
Release Date2023-10-10
Release Version1
Sakda Khoomrung Sakda Khoomrung
https://dx.doi.org/10.21228/M8JX52
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Collection:

Collection ID:CO002980
Collection Summary:Both morning urine and blood samples were collected under sterile conditions within the same day of biopsy/recruitment. Urine samples were centrifuged at 3,500 rpm for 10 min at 4°C. The supernatant was then aliquoted and stored at −80°C until the analysis. Common blood biochemical parameters were measured by an ISO 15189 accredited laboratory. Serum creatinine (SCr) and urine creatinine (UCr) were measured by an enzymatic assay using a Dimension ExL analyzer (Siemens Healthcare Diagnostics, Newark, DE, USA). Urine protein (Uprot) was measured by a modified pyrogallol red-molybdate method. Uprot was reported as urine protein creatinine ratio (UPCR in mg/mgCr). The estimated glomerular filtration rate (eGFR in mL/min/1.73 m2) was calculated using the CKD-EPI equation (Levey et al., 2009):
Sample Type:Urine
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