Summary of Study ST002874

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001796. The data can be accessed directly via it's Project DOI: 10.21228/M8JX52 This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002874
Study TitleQuantification of metabolites in kynurenine pathway
Study SummaryUrine samples were collected from two independent cohorts. Patients with LN were classified into proliferative (class III/IV) and membranous (class V) by kidney histopathology. Quantification of metabolites in kynurenine pathway was performed using LC-MS/MS.
Institute
Mahidol University
DepartmentSiriraj Metabolomics and Phenomics Center
LaboratorySiriraj Center of Research Excellence in Metabolomics and Systems Biology
Last NameKhoomrung
First NameSakda
Address2 Wanglang Road Bangkoknoi, Bangkok 10700, Thailand
Emailsakda.kho@mahidol.edu
Phone024195511
Submit Date2023-09-25
Num Groups2
Total Subjects117
Publicationshttps://doi.org/10.1016/j.isci.2021.103355
Raw Data AvailableYes
Raw Data File Type(s)raw(Waters)
Analysis Type DetailLC-MS
Release Date2023-10-10
Release Version1
Sakda Khoomrung Sakda Khoomrung
https://dx.doi.org/10.21228/M8JX52
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN004711
Analysis type MS
Chromatography type Normal phase
Chromatography system Waters Acquity I-Class
Column Waters ACQUITY UPLC HSS T3 (100 x 2.1mm,1.8um)
MS Type ESI
MS instrument type Single quadrupole
MS instrument name Waters Xevo-TQ-S
Ion Mode POSITIVE
Units ng/ml

MS:

MS ID:MS004457
Analysis ID:AN004711
Instrument Name:Waters Xevo-TQ-S
Instrument Type:Single quadrupole
MS Type:ESI
MS Comments:Quantitative analysis (absolute quantification) was achieved by external calibration curves of each standard prepared in pooled urine samples (standard addition) (Limjiasahapong et al., 2021). The linear ranges of the calibration standards are as follows: 3.5–1,000 ng/mL for Ant; 4.5–80 ng/mL for Cin; 8–2,500 ng/ml for Kyna; 8–5,000 ng/ml for Kyn; 1.4–400 ng/ml for Pic; 40–5000 ng/ml for Qui; 7–2000 ng/ml for Trp; 2–200 ng/ml for Xan; 900–14,000 ng/ml for 3OH-Kyn; 300–2,500 ng/ml for 3OH-Ant and 8–2,000 ng/ml for Ant-C13.
Ion Mode:POSITIVE
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