Summary of Study ST001413
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000969. The data can be accessed directly via it's Project DOI: 10.21228/M8FD5Z This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST001413 |
Study Title | Metabolomic and Transcriptomic Signatures of Prenatal Excessive Methionine in Mice |
Study Type | MS Analysis |
Study Summary | Micronutrients are key regulators of prenatal one-carbon (C1) metabolism. We show here that prenatal excessive methionine (MET), a principal micronutrient and methyl-donor, produces in early life stages significant changes in the components of brain C1 pathways and other metabolic pathways including glutamate transmission, mitochondrial function, and lipid metabolism. |
Institute | University of California, Irvine |
Department | Department of Pharmaceutical Sciences and Department of Computer Science |
Laboratory | Amal Alachkar Group. Pierre Baldi Group |
Last Name | Chen |
First Name | Siwei |
Address | 66304 Verano Place Rd. South |
siweic@uci.edu | |
Phone | 2066585923 |
Submit Date | 2020-06-24 |
Num Groups | 4 |
Total Subjects | 28 |
Num Males | 28 |
Raw Data Available | Yes |
Raw Data File Type(s) | wiff |
Analysis Type Detail | LC-MS |
Release Date | 2020-07-24 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Treatment:
Treatment ID: | TR001502 |
Treatment Summary: | Swiss Webster mice, 8-9 weeks’ age, were obtained from Charles River Laboratories (Wilmington, MA). One male and two female mice were group-housed and maintained on a 12- hours light/dark cycle (light on at 7:00 am) with food and water available ad libitum. Pregnant mice were individually housed from the thirteen day of pregnancy (gestational day 13) until delivery. Pregnant mice that mated with the same male mouse were subcutaneously administered with L-Methionine (MET) at a dose of 750 mg/kg (Sigma-Aldrich) or saline (SAL) twice a day for seven to eight consecutive days from gestational day 14 until delivery. |