Summary of Study ST001413

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000969. The data can be accessed directly via it's Project DOI: 10.21228/M8FD5Z This work is supported by NIH grant, U2C- DK119886.


Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST001413
Study TitleMetabolomic and Transcriptomic Signatures of Prenatal Excessive Methionine in Mice
Study TypeMS Analysis
Study SummaryMicronutrients are key regulators of prenatal one-carbon (C1) metabolism. We show here that prenatal excessive methionine (MET), a principal micronutrient and methyl-donor, produces in early life stages significant changes in the components of brain C1 pathways and other metabolic pathways including glutamate transmission, mitochondrial function, and lipid metabolism.
University of California, Irvine
DepartmentDepartment of Pharmaceutical Sciences and Department of Computer Science
LaboratoryAmal Alachkar Group. Pierre Baldi Group
Last NameChen
First NameSiwei
Address66304 Verano Place Rd. South
Submit Date2020-06-24
Num Groups4
Total Subjects28
Num Males28
Raw Data AvailableYes
Raw Data File Type(s)wiff
Analysis Type DetailLC-MS
Release Date2020-07-24
Release Version1
Siwei Chen Siwei Chen application/zip

Select appropriate tab below to view additional metadata details:


Treatment ID:TR001502
Treatment Summary:Swiss Webster mice, 8-9 weeks’ age, were obtained from Charles River Laboratories (Wilmington, MA). One male and two female mice were group-housed and maintained on a 12- hours light/dark cycle (light on at 7:00 am) with food and water available ad libitum. Pregnant mice were individually housed from the thirteen day of pregnancy (gestational day 13) until delivery. Pregnant mice that mated with the same male mouse were subcutaneously administered with L-Methionine (MET) at a dose of 750 mg/kg (Sigma-Aldrich) or saline (SAL) twice a day for seven to eight consecutive days from gestational day 14 until delivery.