Summary of Study ST002772

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001729. The data can be accessed directly via it's Project DOI: 10.21228/M86X4K This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002772
Study TitleDay-night fluctuations in Cerebrospinal fluid metabolomics
Study TypeCircadian (Naïve animals)
Study SummaryThis study was designed to investigate whether the molecular drivers underlying the diurnal fluctuation of CSF secretion rate could be found in either the choroid plexus tissue itself and/or in the CSF surrounding it. Male Sprague-Dawley rats, kept in light-controlled 12:12 conditions, presented with diurnally modulated CSF metabolite composition. This change was accompanied with differential expression of 2778 genes within the choroid plexus, with several plasma membrane transporters and CLOCK-associated genes diurnally modulated.
University of Copenhagen
DepartmentDepartment of Neuroscience
LaboratoryMacAulay Group
Last NameEdelbo
First NameBeatriche
AddressBlegdamsvej 3B
Submit Date2023-07-04
Num Groups2
Total Subjects25
Num Males25
Study Comments2 night animals were excluded due to comments regarding sampling/behavior (N4 and N11)
PublicationsDay-night fluctuations in choroid plexus transcriptomics and cerebrospinal fluid metabolomics
Raw Data AvailableYes
Raw Data File Type(s)mzML, raw(Thermo)
Analysis Type DetailLC-MS
Release Date2023-07-25
Release Version1
Beatriche Edelbo Beatriche Edelbo application/zip

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Treatment ID:TR002888
Treatment Summary:No treatment, natural light and dark phase, anesthesia during sampling 6 mg/ml xylazine + 60 mg/ml ketamine. Animals was housed at light-controlled facility a minimum of 1½ weeks prior to experimentation.