Summary of Study ST001317

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000894. The data can be accessed directly via it's Project DOI: 10.21228/M84D6J This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001317
Study TitleDynamics of Exposure, Phthalates, and Asthma in a Randomized Trial (DEPART)
Study TypeCHEAR Study
Study SummaryProject will investigate relationships between phthalate exposure, pediatric asthma health, and underlying biological pathways of toxicity among a rural, underserved Latino population located in Yakima Valley, WA. DEPART will benefit from the original study’s (HAPI’s) robust longitudinal repeat-measure design and community-engaged framework. DEPART will add new measurements including concentrations of urinary phthalate monoester metabolites and biomarkers of oxidative stress to better characterize exposure-response associations. This project’s primary goal is to deepen the understanding of pathophysiological phenomena underlying exposure-response relationships between phthalates and asthma health. Our specific aims are: (1) Characterize associations between urinary phthalate metabolite concentrations and short-term asthma morbidity, and (2) Determine individual relationships between urinary phthalate metabolite concentrations, short-term asthma morbidity, and biomarkers for oxidative stress to assess the potential for a mediating effect by oxidative stress. Covariates of interest will include atopic status, randomized intervention grouping, and the caregiver psychosocial stress assessment.
Icahn School of Medicine at Mount Sinai
DepartmentDepartment of Environmental Medicine and Public Health
LaboratoryMount Sinai CHEAR Untargeted Laboratory Hub
Last NameWalker
First NameDouglas
AddressAtran Building RM AB3-39, 1428 Madison Ave
Submit Date2020-02-05
Raw Data AvailableYes
Raw Data File Type(s)d
Chear StudyYes
Analysis Type DetailLC-MS
Release Date2021-08-31
Release Version1
Douglas Walker Douglas Walker application/zip

Select appropriate tab below to view additional metadata details:

Combined analysis:

Analysis ID AN002192 AN002193
Analysis type MS MS
Chromatography type HILIC Reversed phase
Chromatography system Agilent 1290 Infinity II Agilent 1290 Infinity II
Column SeQuant ZIC-HILIC (100 x 2.1mm,3.5um,100 Å) Agilent Zorbax Eclipse Plus C18, RRHD (50 × 2.1 mm,1.8 um)
MS instrument type QTOF QTOF
MS instrument name Agilent 6550 QTOF Agilent 6550 QTOF
Units Peak Intensity Peak Intensity