Summary of Study ST001317
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000894. The data can be accessed directly via it's Project DOI: 10.21228/M84D6J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001317 |
| Study Title | Dynamics of Exposure, Phthalates, and Asthma in a Randomized Trial (DEPART) |
| Study Type | CHEAR Study |
| Study Summary | Project will investigate relationships between phthalate exposure, pediatric asthma health, and underlying biological pathways of toxicity among a rural, underserved Latino population located in Yakima Valley, WA. DEPART will benefit from the original study’s (HAPI’s) robust longitudinal repeat-measure design and community-engaged framework. DEPART will add new measurements including concentrations of urinary phthalate monoester metabolites and biomarkers of oxidative stress to better characterize exposure-response associations. This project’s primary goal is to deepen the understanding of pathophysiological phenomena underlying exposure-response relationships between phthalates and asthma health. Our specific aims are: (1) Characterize associations between urinary phthalate metabolite concentrations and short-term asthma morbidity, and (2) Determine individual relationships between urinary phthalate metabolite concentrations, short-term asthma morbidity, and biomarkers for oxidative stress to assess the potential for a mediating effect by oxidative stress. Covariates of interest will include atopic status, randomized intervention grouping, and the caregiver psychosocial stress assessment. |
| Institute | Icahn School of Medicine at Mount Sinai |
| Department | Department of Environmental Medicine and Public Health |
| Laboratory | Mount Sinai CHEAR Untargeted Laboratory Hub |
| Last Name | Walker |
| First Name | Douglas |
| Address | Atran Building RM AB3-39, 1428 Madison Ave |
| douglas.walker@mssm.edu | |
| Phone | 212-241-9891 |
| Submit Date | 2020-02-05 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | d |
| Chear Study | Yes |
| Analysis Type Detail | LC-MS |
| Release Date | 2021-08-31 |
| Release Version | 1 |
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Project:
| Project ID: | PR000894 |
| Project DOI: | doi: 10.21228/M84D6J |
| Project Title: | Home Air in Agriculture Pediatric Intervention Trial (HAPI) |
| Project Summary: | The HAPI study seeks to leverage a community-engaged research approach to reduce exposure to asthmagens in the homes of an environmental justice community of Latino children residing in an area of intense dairy and crop based agricultural production. These children with asthma experience high morbidity and our preliminary research finds significant effects of ambient concentrations of fine particulate matter and ammonia. Yet children spend the majority of their time indoors. Studies conducted in urban settings demonstrate that indoor particulate matter (PM) influences asthma outcomes and HEPA (high efficiency particulate air) cleaners can reduce indoor and ambient generated PM. Data on asthma in rural settings is sparse and trials incorporating HEPA portable air cleaners are lacking. This study seeks to characterize key indoor pollutant exposures for 80 children with asthma who reside within 400 meters of crop production or dairy operations. Prioritizing methods with low participant burden as well as innovative approaches, we will evaluate the effectiveness of the enhanced intervention on 1) Reducing indoor measures of PM and NH3 across seasons, 2. Improving clinically relevant measures of asthma health (Asthma Control Test, lung function, self-reported symptom days, oral steroid treatment, unscheduled clinical utilization), and 3. Reducing biomarkers of inflammation - urinary cysteine leukotriene (uLTE4) and exhaled nitric oxide (eNO). Caregiver psychosocial stress and behavioral components will be evaluated as mediators of these effects. The study design, procedures, translation of research results for multiple stakeholders and development of an environmental action plan to control/eliminate exposures are conducted within El Proyecto Bienestar, a longstanding UW-community research to action partnership. The project incorporates each of the NIEHS 2012-17 strategic themes and directly addresses 7 of the 11 sub goals. |
| Institute: | University of Washington |
| Last Name: | Karr |
| First Name: | Catherine |
| Address: | 301, Roosevelt One Building, Seattle, WA |
| Email: | ckarr@uw.edu |
| Phone: | 206-616-4355 |
| Funding Source: | National Institute of Environmental Health and Science (NIEHS), 5R01ES023510-03 |
| Contributors: | Sheela Sathyanarayana, Ryan Babadi, Robert Wright, Lauren Petrick, Douglas Walker, Manish Arora |
