Summary of Study ST001317
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000894. The data can be accessed directly via it's Project DOI: 10.21228/M84D6J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001317 |
| Study Title | Dynamics of Exposure, Phthalates, and Asthma in a Randomized Trial (DEPART) |
| Study Type | CHEAR Study |
| Study Summary | Project will investigate relationships between phthalate exposure, pediatric asthma health, and underlying biological pathways of toxicity among a rural, underserved Latino population located in Yakima Valley, WA. DEPART will benefit from the original study’s (HAPI’s) robust longitudinal repeat-measure design and community-engaged framework. DEPART will add new measurements including concentrations of urinary phthalate monoester metabolites and biomarkers of oxidative stress to better characterize exposure-response associations. This project’s primary goal is to deepen the understanding of pathophysiological phenomena underlying exposure-response relationships between phthalates and asthma health. Our specific aims are: (1) Characterize associations between urinary phthalate metabolite concentrations and short-term asthma morbidity, and (2) Determine individual relationships between urinary phthalate metabolite concentrations, short-term asthma morbidity, and biomarkers for oxidative stress to assess the potential for a mediating effect by oxidative stress. Covariates of interest will include atopic status, randomized intervention grouping, and the caregiver psychosocial stress assessment. |
| Institute | Icahn School of Medicine at Mount Sinai |
| Department | Department of Environmental Medicine and Public Health |
| Laboratory | Mount Sinai CHEAR Untargeted Laboratory Hub |
| Last Name | Walker |
| First Name | Douglas |
| Address | Atran Building RM AB3-39, 1428 Madison Ave |
| douglas.walker@mssm.edu | |
| Phone | 212-241-9891 |
| Submit Date | 2020-02-05 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | d |
| Chear Study | Yes |
| Analysis Type Detail | LC-MS |
| Release Date | 2021-08-31 |
| Release Version | 1 |
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Treatment:
| Treatment ID: | TR001406 |
| Treatment Summary: | HAPI is a randomized controlled trial with subject recruitment utilizing an existing community health worker delivered asthma education program operated by the region's federally qualified health center. HAPI eligibility criteria includes: (i) age 6 – 12 years, (ii) asthma not well controlled, (iii) no household smokers, and (iv) residence within 400m of dairy/crop production. Recruited subjects are randomized to a standard educational program or an enhanced intervention, which includes 2 portable room HEPA cleaners – one in the child sleeping area and one in the living room – with PM and ammonia (NH3) reduction filters. Enrollment occurs on a rolling basis, and each subject undergoes an initial baseline clinic visit and three additional health assessment in-home visits – the first and last of which occurring alongside environmental sampling. Subjects are randomized after the first home visit. Subjects in the control (standard asthma education only) group will receive HEPA cleaners at the end of their study year, if requested. The study setting is Yakima County, WA. |
