Summary of Study ST001775
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001129. The data can be accessed directly via it's Project DOI: 10.21228/M8RX1D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST001775 |
| Study Title | Plasma metabolomics of diverse mouse strains infected with Plasmodium chabaudi |
| Study Summary | To uncover links between metabolism and disease severity in murine malaria, we performed plasma metabolomics via Metabolon on eight inbred, Plasmodium chabaudi-infected mouse strains with diverse disease phenotypes. We sacrificed and collected plasma from >=3 mice per strain per day of acute infection alongside uninfected control mice (approximately days 5-12 depending on mouse strain). We collected disease severity data, e.g. weight loss, liver enzymes, and anemia, concurrently. Together, these data enable 1) a picture of strain-specific and conserved metabolic responses during acute malaria, and 2) a comparison between metabolic responses and disease severity. |
| Institute | Stanford University |
| Department | Microbiology & Immunology |
| Laboratory | David Schneider |
| Last Name | Schneider |
| First Name | David |
| Address | 299 Campus Drive, Stanford, CA 94305 |
| dschneid@stanford.edu | |
| Phone | 650-724-8064 |
| Submit Date | 2021-04-11 |
| Num Groups | 8 mouse strains +/- Plasmodium infection |
| Total Subjects | 369 |
| Num Females | 369 |
| Analysis Type Detail | LC-MS |
| Release Date | 2021-05-21 |
| Release Version | 1 |
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Combined analysis:
| Analysis ID | AN002882 |
|---|---|
| Analysis type | MS |
| Chromatography type | Reversed phase |
| Chromatography system | Waters Acquity |
| Column | Waters Acquity BEH C8 (100 x 2.1mm,1.7um) |
| MS Type | ESI |
| MS instrument type | Orbitrap |
| MS instrument name | Thermo Q Exactive Orbitrap |
| Ion Mode | POSITIVE |
| Units | ion counts |
