Summary of Study ST001775

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001129. The data can be accessed directly via it's Project DOI: 10.21228/M8RX1D This work is supported by NIH grant, U2C- DK119886.

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Study IDST001775
Study TitlePlasma metabolomics of diverse mouse strains infected with Plasmodium chabaudi
Study SummaryTo uncover links between metabolism and disease severity in murine malaria, we performed plasma metabolomics via Metabolon on eight inbred, Plasmodium chabaudi-infected mouse strains with diverse disease phenotypes. We sacrificed and collected plasma from >=3 mice per strain per day of acute infection alongside uninfected control mice (approximately days 5-12 depending on mouse strain). We collected disease severity data, e.g. weight loss, liver enzymes, and anemia, concurrently. Together, these data enable 1) a picture of strain-specific and conserved metabolic responses during acute malaria, and 2) a comparison between metabolic responses and disease severity.
Institute
Stanford University
DepartmentMicrobiology & Immunology
LaboratoryDavid Schneider
Last NameSchneider
First NameDavid
Address299 Campus Drive, Stanford, CA 94305
Emaildschneid@stanford.edu
Phone650-724-8064
Submit Date2021-04-11
Num Groups8 mouse strains +/- Plasmodium infection
Total Subjects369
Num Females369
Analysis Type DetailLC-MS
Release Date2021-05-21
Release Version1
David Schneider David Schneider
https://dx.doi.org/10.21228/M8RX1D
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Subject:

Subject ID:SU001852
Subject Type:Mammal
Subject Species:Mus musculus
Taxonomy ID:10090
Genotype Strain:C57BL/6 ; PWK/PhJ ; WSB/EiJ ; NZO/HILtJ ; A/J ; 129S1/SvImJ ; CAST/EiJ ; NOD/ShiLtJ
Age Or Age Range:8-12 weeks
Gender:Female
Animal Animal Supplier:JAX (except C57BL/6, who came from Charles River)
Animal Housing:standard
Animal Light Cycle:standard
Animal Feed:TEKLAD global
Animal Water:standard
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