Summary of Study ST002153

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001366. The data can be accessed directly via it's Project DOI: 10.21228/M85115 This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002153
Study TitleData from plasma metabolome analysis of APP-KI and Wild type mice treated with B. breve MCC1274
Study SummaryRecently, we showed that administration of B. breve MCC1274 reduced amyloid-beta production, inhibited microglial activation, and suppressed inflammatory responses in the brains of APP knock-in (AppNL-G-F) mice. To elucidate the mechanism of action of this probiotic strain in an Alzheimer's disease-like model, we orally fed 3-month-old mice with B. breve MCC1274 or saline for 4 months and comprehensively investigated metabolites in plasma using CE-FTMS and LC-TOFMS.
Morinaga milk industry CO., LTD.
DepartmentNext generation science institute
LaboratoryFrontier research section
Last NameOhno
First NameKazuya
Address1-83 5-Chome Higashihara, Zama-city, Kanagawa-Pref. Japan
Submit Date2022-04-18
Analysis Type DetailLC-MS
Release Date2022-10-03
Release Version1
Kazuya Ohno Kazuya Ohno application/zip

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Combined analysis:

Analysis ID AN003526 AN003527
Analysis type MS MS
Chromatography type Normal phase Reversed phase
Chromatography system Agilent 1260 Agilent 1200
Column fused silica capillary (50 μm i.d. × 80 cm total length; Polymicro Technologies, Inc., Phoenix, AZ) ODS
MS instrument type Orbitrap Triple TOF
MS instrument name Thermo Q Exactive Plus Orbitrap Agilent 6210 TOF
Units peak area peak area