Summary of Study ST002153
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001366. The data can be accessed directly via it's Project DOI: 10.21228/M85115 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002153 |
| Study Title | Data from plasma metabolome analysis of APP-KI and Wild type mice treated with B. breve MCC1274 |
| Study Summary | Recently, we showed that administration of B. breve MCC1274 reduced amyloid-beta production, inhibited microglial activation, and suppressed inflammatory responses in the brains of APP knock-in (AppNL-G-F) mice. To elucidate the mechanism of action of this probiotic strain in an Alzheimer's disease-like model, we orally fed 3-month-old mice with B. breve MCC1274 or saline for 4 months and comprehensively investigated metabolites in plasma using CE-FTMS and LC-TOFMS. |
| Institute | Morinaga milk industry CO., LTD. |
| Department | Next generation science institute |
| Laboratory | Frontier research section |
| Last Name | Ohno |
| First Name | Kazuya |
| Address | 1-83 5-Chome Higashihara, Zama-city, Kanagawa-Pref. Japan |
| kazuya-oono443@morinagamilk.co.jp | |
| Phone | 81462523067 |
| Submit Date | 2022-04-18 |
| Analysis Type Detail | LC-MS |
| Release Date | 2022-10-03 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
| Analysis ID | AN003526 | AN003527 |
|---|---|---|
| Analysis type | MS | MS |
| Chromatography type | Normal phase | Reversed phase |
| Chromatography system | Agilent 1260 | Agilent 1200 |
| Column | fused silica capillary (50 μm i.d. × 80 cm total length; Polymicro Technologies, Inc., Phoenix, AZ) | ODS |
| MS Type | ESI | ESI |
| MS instrument type | Orbitrap | TOF |
| MS instrument name | Thermo Q Exactive Plus Orbitrap | Agilent 6210 TOF |
| Ion Mode | UNSPECIFIED | UNSPECIFIED |
| Units | peak area | peak area |
Chromatography:
| Chromatography ID: | CH002604 |
| Instrument Name: | Agilent 1260 |
| Column Name: | fused silica capillary (50 μm i.d. × 80 cm total length; Polymicro Technologies, Inc., Phoenix, AZ) |
| Internal Standard: | H3304-1002, Human Metabolome Technologies, Inc. (HMT), Tsuruoka, Yamagata, Japan |
| Solvent A: | commercial electrophoresis buffer (H3301-1001; I3302-1023 for cation; anion analyses, respectively, HMT) |
| Chromatography Type: | Normal phase |
| Chromatography ID: | CH002605 |
| Instrument Name: | Agilent 1200 |
| Column Name: | ODS |
| Internal Standard: | H3304-1002, Human Metabolome Technologies, Inc. (HMT), Tsuruoka, Yamagata, Japan |
| Chromatography Type: | Reversed phase |
