Summary of Study ST002153
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001366. The data can be accessed directly via it's Project DOI: 10.21228/M85115 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST002153 |
Study Title | Data from plasma metabolome analysis of APP-KI and Wild type mice treated with B. breve MCC1274 |
Study Summary | Recently, we showed that administration of B. breve MCC1274 reduced amyloid-beta production, inhibited microglial activation, and suppressed inflammatory responses in the brains of APP knock-in (AppNL-G-F) mice. To elucidate the mechanism of action of this probiotic strain in an Alzheimer's disease-like model, we orally fed 3-month-old mice with B. breve MCC1274 or saline for 4 months and comprehensively investigated metabolites in plasma using CE-FTMS and LC-TOFMS. |
Institute | Morinaga milk industry CO., LTD. |
Department | Next generation science institute |
Laboratory | Frontier research section |
Last Name | Ohno |
First Name | Kazuya |
Address | 1-83 5-Chome Higashihara, Zama-city, Kanagawa-Pref. Japan |
kazuya-oono443@morinagamilk.co.jp | |
Phone | 81462523067 |
Submit Date | 2022-04-18 |
Analysis Type Detail | LC-MS |
Release Date | 2022-10-03 |
Release Version | 1 |
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Project:
Project ID: | PR001366 |
Project DOI: | doi: 10.21228/M85115 |
Project Title: | Improvement of cognitive function by B. breve MCC1274 and elucidation of its mechanism of action |
Project Summary: | Although many studies have suggested that probiotics could modulate various brain functions via the gut-brain axis, little is known about the mechanism underlying this process. We previously reported the beneficial effects of a probiotic strain, Bifidobacterium breve MCC1274, on cognitive function in preclinical and clinical studies. Recently, we showed that administration of this strain reduced amyloid-beta production, inhibited microglial activation, and suppressed inflammatory responses in the brains of APP knock-in (AppNL-G-F) mice. To elucidate the mechanism of action of this probiotic strain in an Alzheimer's disease-like model, we orally fed 3-month-old mice with B. breve MCC1274 or saline for 4 months and comprehensively investigated metabolites in plasma using CE-FTMS and LC-TOFMS. |
Institute: | Morinaga milk industry CO., LTD. |
Department: | Next generation science institute |
Laboratory: | Frontier research section |
Last Name: | Ohno |
First Name: | Kazuya |
Address: | 1-83 5-Chome Higashihara, Zama-city, Kanagawa-Pref. Japan |
Email: | kazuya-oono443@morinagamilk.co.jp |
Phone: | 81462523067 |