Summary of study ST000337

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000269. The data can be accessed directly via it's Project DOI: 10.21228/M81307 This work is supported by NIH grant, U2C- DK119886.

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Study IDST000337
Study TitleMetabolomics Approach to Allograft Assessment in Liver Transplantation
Study TypeRetrospective analysis of biobanked liver tissue from organ donors
Study SummaryThis pilot study is designed to apply several types of metabolomic analysis for liver allograft assessment with the aim of identifying candidate biomarkers for allograft function and to develop a methodology that could be applied to larger scale studies. The three main categories of metabolomic analysis are reflected in each of the specific aims, including a targeted profiling of central carbon metabolism, open lipidomic and metabolomic profiling for hypothesis generation and MALDI-IMS for tissue-based spatial analysis. Each of these approaches offers potential benefits that could be optimized in a protocol for larger scale studies depending the results of the pilot investigations.
Institute
Ochsner Multi-Organ Transplant Institute
DepartmentSECIM
LaboratoryAbdominal Organ Transplantation
Last NameSeal
First NameJohn
Address1514 Jefferson Highway, New Orleans, LA 70121
EmailJohn.Seal@ochsner.org
Phone504-232-4253
Submit Date2016-01-17
Num Groups3
Total SubjectsTargeted analysis and open profiling: Control group - standard criteria donor (N=15); Experimental group - donation-after-cardiac-death donors (N=10). MALDI-IMS - standard criteria donor (N=10)
Analysis Type DetailLC-MS
Release Date2017-01-17
Release Version1
John Seal John Seal
https://dx.doi.org/10.21228/M81307
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Collection:

Collection ID:CO000351
Collection Summary:A wedge biopsy of the right lobe of the liver is routinely obtained prior to transplantation. The sample is immediately flash frozen in the operating room and subsequently transferred to Ochsner Biobank for sample storage.
Sample Type:Liver Tissue
Collection Method:Open biopsy during cold storage preservation of organ for transplant
Collection Location:Operating room of liver transplant during
Collection Frequency:Single sample prior to transplant
Collection Duration:Not applicable
Collection Time:Not applicable
Volumeoramount Collected:~50mg
Storage Conditions:-180 degree C, liquid nitrogen vapor phase
Collection Vials:ThermoScientific CryoTube vials, 1.8mL
Storage Vials:ThermoScientific CryoTube vials, 1.8mL
Collection Tube Temp:-70 degree liguid nitrogen flash freezing
Additives:None
Blood Serum Or Plasma:N/A
Tissue Cell Identification:N/A
Tissue Cell Quantity Taken:N/A
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