Summary of Study ST000093

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000085. The data can be accessed directly via it's Project DOI: 10.21228/M8JS3X This work is supported by NIH grant, U2C- DK119886.

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Study IDST000093
Study TitleMetabolomics Analysis of Frontal Fibrosing Alopecia
Study TypeUnaffected and Affected patient scalp biopsies
Study SummaryScarring alopecia consists of a collection of disorders characterized by destruction of hair follicles, replacement with fibrous scar tissue, and irreversible hair loss. Alopecia affects men and women worldwide and can be a significant source of psychological stress and depression for affected individuals. The purpose of this study was to explore metabolic profiles in scalp tissue samples from normal control subjects (n=6) and in matched samples obtained from affected (n=12) and unaffected (n=12) areas of the scalp in patients with lymphocytic Frontal Fibrosing Alopecia (FFA). Frontal fibrosing alopecia results from destruction of hair follicles by an inflammatory lymphocytic infiltrate that is localized around the upper portion of the hair follicle.
Institute
Case Western Reserve University
DepartmentDermatology
LaboratoryKarnik Lab
Last NameKarnik
First NamePratima
Emailpsk11@case.edu
Phone216-368-0209
Submit Date2014-07-24
Num Groups3 groups-Paired unaffected and affected (n=12),Normals(n=6)
Total SubjectsPatients (N=12), Normals (N=6)
Study CommentsAffected scalp biopsies were obtained from frontal scalp, Unaffected from occipital scalp. Normal scalp biopsies were obtained from the occipital scalp.
Raw Data AvailableNo
Analysis Type DetailGC-MS/LC-MS
Release Date2014-07-26
Release Version1
Pratima Karnik Pratima Karnik
https://dx.doi.org/10.21228/M8JS3X
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id condition location
SA005255Patient_138_FFA_AFFA affected frontal scalp
SA005256Patient_144_FFA_AFFA affected frontal scalp
SA005257Patient_143_FFA_AFFA affected frontal scalp
SA005258Patient_146_FFA_AFFA affected frontal scalp
SA005259Patient_147_FFA_AFFA affected frontal scalp
SA005260Patient_150_FFA_AFFA affected frontal scalp
SA005261Patient_149_FFA_AFFA affected frontal scalp
SA005262Patient_142_FFA_AFFA affected frontal scalp
SA005263Patient_145_FFA_AFFA affected frontal scalp
SA005264Patient_140_FFA_AFFA affected frontal scalp
SA005265Patient_139_FFA_AFFA affected frontal scalp
SA005266Patient_141_FFA_AFFA affected frontal scalp
SA005267Patient_150_FFA_UFFA unaffected occipital scalp
SA005268Patient_142_FFA_UFFA unaffected occipital scalp
SA005269Patient_138_FFA_UFFA unaffected occipital scalp
SA005270Patient_149_FFA_UFFA unaffected occipital scalp
SA005271Patient_139_FFA_UFFA unaffected occipital scalp
SA005272Patient_147_FFA_UFFA unaffected occipital scalp
SA005273Patient_143_FF_UFFA unaffected occipital scalp
SA005274Patient_146_FFA_UFFA unaffected occipital scalp
SA005275Patient_144_FFA_UFFA unaffected occipital scalp
SA005276Patient_141_FFA_UFFA unaffected occipital scalp
SA005277Patient_140_FFA_UFFA unaffected occipital scalp
SA005278Patient_145_FFA_UFFA unaffected occipital scalp
SA005279Patient_GN048_NormalScalp biopsy normal NA
SA005280Patient_DN338_NormalScalp biopsy normal NA
SA005281Patient_LN339_NormalScalp biopsy normal NA
SA005282Patient_TN089_NormalScalp biopsy normal NA
SA005283Patient_PN200_NormalScalp biopsy normal NA
SA005284Patient_KN336_NormalScalp biopsy normal NA
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