Summary of Study ST000093

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000085. The data can be accessed directly via it's Project DOI: 10.21228/M8JS3X This work is supported by NIH grant, U2C- DK119886.


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Study IDST000093
Study TitleMetabolomics Analysis of Frontal Fibrosing Alopecia
Study TypeUnaffected and Affected patient scalp biopsies
Study SummaryScarring alopecia consists of a collection of disorders characterized by destruction of hair follicles, replacement with fibrous scar tissue, and irreversible hair loss. Alopecia affects men and women worldwide and can be a significant source of psychological stress and depression for affected individuals. The purpose of this study was to explore metabolic profiles in scalp tissue samples from normal control subjects (n=6) and in matched samples obtained from affected (n=12) and unaffected (n=12) areas of the scalp in patients with lymphocytic Frontal Fibrosing Alopecia (FFA). Frontal fibrosing alopecia results from destruction of hair follicles by an inflammatory lymphocytic infiltrate that is localized around the upper portion of the hair follicle.
Case Western Reserve University
LaboratoryKarnik Lab
Last NameKarnik
First NamePratima
Submit Date2014-07-24
Num Groups3 groups-Paired unaffected and affected (n=12),Normals(n=6)
Total SubjectsPatients (N=12), Normals (N=6)
Study CommentsAffected scalp biopsies were obtained from frontal scalp, Unaffected from occipital scalp. Normal scalp biopsies were obtained from the occipital scalp.
Raw Data AvailableNo
Analysis Type DetailGC-MS/LC-MS
Release Date2014-07-26
Release Version1
Pratima Karnik Pratima Karnik application/zip

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Project ID:PR000085
Project DOI:doi: 10.21228/M8JS3X
Project Title:Mitochondrial Dysfunction in Frontal Fibrosing Alopecia
Project Summary:The goal of this study was to characterize metabolic drift associated with lymphocytic frontal fibrosing alopecia (FFA), comparing same-patient affected/unaffected area tissues as well as control patient tissue.
Institute:Case Western Reserve University
Laboratory:Karnik Laboratory
Last Name:Karnik
First Name:Pratima
Funding Source:NIAMS grant R01 AR056245 and NIH Common Fund grant (Metabolomics) R01 AR056245S1 grants to Pratima Karnik