Summary of Study ST002584

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001664. The data can be accessed directly via it's Project DOI: 10.21228/M8MH79 This work is supported by NIH grant, U2C- DK119886.


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Study IDST002584
Study TitleMetabolomics analysis of ALDH1L1-expressing HuH7 cell lines.
Study SummaryOne-carbon metabolism is utilized for the de novo synthesis of purines. Given that tumor cells require large amounts of nucleotides, they are highly dependent on one-carbon metabolism. Among the one-carbon-metabolizing enzymes, the aldehyde dehydrogenase 1 family member L1 (ALDH1L1), which catalyzes 10-formyltetrahydrofolate to tetrahydrofolate, is considered a tumor suppressor gene, as its expression is reported to be attenuated or diminished in hepatocellular carcinoma. To clarify the effect of ALDH1L1 expression, we generated control and ALDH1L1-expressing HuH-7 (H7-1L1) cells, and measured the amounts of intracellular metabolites in both control and ALDH1L1-expressing by CE-TOFMS analysis.
Tohoku Medical and Pharmaceutical University
Last NameSasaki
First NameMasato
Address4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan
Submit Date2023-04-21
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2023-05-01
Release Version1
Masato Sasaki Masato Sasaki application/zip

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Subject ID:SU002686
Subject Type:Cultured cells
Subject Species:Homo sapiens
Taxonomy ID:9606