Summary of Study ST002567
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001654. The data can be accessed directly via it's Project DOI: 10.21228/M8WX3D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST002567 |
Study Title | Metabolomics of Human islets treated with DHT and high-glucose challenge |
Study Summary | Dihydrotestosterone (DHT) driven Androgen receptor activation in pancreatic beta-cells leads to the amplification of GLP-1R-mediated insulin exocytosis. Here we study the impact of DHT on the metabolic architecture of human pancreatic islets upon stimulation with DHT at high (16.7mM) and low (2.8mM) Glucose. |
Institute | Tulane University School of Medicine |
Last Name | Qadir |
First Name | Mirza Muhammad Fahd |
Address | SOM RM2301/Endocrinology |
mqadir@tulane.edu | |
Phone | 5049884646 |
Submit Date | 2023-04-17 |
Raw Data Available | Yes |
Raw Data File Type(s) | mzML |
Analysis Type Detail | LC-MS |
Release Date | 2023-04-19 |
Release Version | 1 |
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Treatment:
Treatment ID: | TR002680 |
Treatment Summary: | Human islets were treated overnight with 10nM DHT or EtOH in a humidified incubator containing 4% CO2 at 37°C and then batched in groups of 100 islets in microcentrifuge tubes and treated for either 30 or 60 minutes with media containing either 2.8mM or 16.7 mM 13C6 glucose; the same DHT or EtOH concentrations were maintained. |
Treatment Compound: | DHT |
Treatment Dose: | 10nM |
Treatment Dosevolume: | 1ul per 1ml media |
Treatment Doseduration: | 24 hours prior to experiment |
Treatment Vehicle: | Ethanol |