Regional Comprehensive Metabolomics Resource Cores (RCMRC)s

RCMRCs are expected to address the need for increasing metabolomics research capacity by providing national leadership in metabolomics research, training, and knowledge dissemination. As part of this endeavor, our RCMRCs provide services for metabolomics research via a Pilot and Feasibility Program.

Michigan Regional Comprehensive Metabolomics Resource Core (MRC2)
Mission Statement
The Michigan Regional Comprehensive Metabolomics Research Core (MRC2) is an entity created to support, integrate and enhance basic and translational research incorporating metabolomics technology.
Areas of Expertise
Consultations in targeted and untargeted metabolomics, study design to data analysis. Development and refinement of visualization tools for diverse data sets. Techniques to perform and analyze in vivo and in vitro fluxomics.
Services
Consultations on topics from study design to data analysis, targeted and untargeted metabolomics, targeted and untargeted lipidomics, in vivo and in vitro fluxomics, statistics and data analysis, data visualization software.
West Coast Central Comprehensive Metabolomics Resource Core (WCMC)
Mission Statement
The NIH West Coast Metabolomics Center extends metabolomics services to investigators in industry and academia while simultaneously advancing the state-of-the art in metabolomics technologies.
Areas of Expertise
Databases, spectral libraries, mass spectrometry, quality-controlled high-throughput metabolomic data in epidemiology studies. Compound identification from untargeted metabolomics. Absolute quantification of target analytes.
Services
Targeted and untargeted analysis of complex lipids, steroids, eicosanoids, oxylipins, primary metabolites, glycans and metabolic imaging. Pathway analysis and advanced statistics. Integration with genomic and proteomic data.
RTI
Mission Statement
The NIH Eastern RCMRC at RTI is guided by RTI’s mission to improve the human condition by turning knowledge into practice. We partner with clinical and translational researchers to promote innovative research and provide training.
Areas of Expertise
Broad spectrum and targeted metabolomics, metallomics, and mineralomics, using mass spectrometry and NMR Spectroscopy. Genomics, cell and animal research, epidemiology, statistics, and synthesis of isotopic labeled standards.
Services
Metabolomics analysis of cells, organ tissues, fluids, and excreta. Statistical and multivariate analysis, pathway analysis, and integration of other clinical and genomics data streams via pathway or mQTL mapping.
Southeast Center for Integrated Metabolomics (SECIM)
Mission Statement
The Southeast Center for Integrated Metabolomics provides state-of-the-art metabolomics services to users in all areas of biomedical, clinical and biological sciences using well defined and emerging technologies.
Areas of Expertise
Liquid chromatography/mass spectrometry (LC/MS), Proton Nuclear Magnetic Resonance Spectroscopy (H- NMR) using high resolution magic angle spinning (HR-MAS), Imaging MS, Isotope Ratio Outlier Analysis (IROA), bioinformatics
Services
Global and targeted analysis of various sample types including urine, cellular extracts from tissue culture, plasma/serum, and tissue specimens. Bio-statistical tools also available to aid in data interpretation.
Resource Center for Stable Isotope-Resolved Metabolomics (RC-SIRM)
Mission Statement
The overall mission is to provide state-of-the art instrumentation, approaches, and interpretation for stable isotope-resolved metabolomics (SIRM), for basic-to-translational systems biochemistry.
Areas of Expertise
SIRM involving integration of high information throughput (HIT) based on NMR and MS techniques. Direct experience expertise in human surgical studies, mice/xenografts, cell cultures, invertebrate, plant, & soil biochemistry.
Services
Sample Core - full core-level attention to sample preparation; Analytical Core - 14.1T & 18.8T NMRs, FTMS (Orbitrap & ICR), GC & LC front ends, ICPMS; Informatics Core - HIT data reduction/interpretation of complex labeling.
Metabolomics Core at Mayo Clinic
Mission Statement
The Mayo Clinic Metabolomics Resource Core integrates state-of-the-art metabolomics with phenotypic characteristics of disease or models of disease to advance understanding of the physiology and diseases, thereby facilitating rapid translation of basic discoveries into improved human health.
Areas of Expertise
metabolic flux analysis, high-resolution high-throughput NMR spectroscopy, bioinformatics
Services
Consultations, quantitative and qualitative large scale metabolomics analysis, measurement of stable isotope enrichment in metabolites, metabolic flux analysis, high-resolution high-throughput NMR spectroscopy, bioinformatics

Regional Comprehensive Metabolomics Resource Cores (RCMRC)s
Michigan Regional Comprehensive Metabolomics Resource Core (MRC)2
NIH West Coast Metabolomics Center at UC Davis
NIH Eastern Regional Comprehensive Metabolomics Resource Core at RTI International
Southeast Center for Integrated Metabolomics (SECIM)
Resource Center for Stable Isotope-Resolved Metabolomics (RC-SIRM)
Metabolomics Core at Mayo Clinic

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